Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition
نویسندگان
چکیده
منابع مشابه
Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition
Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection...
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The definition of haplotype blocks of single-nucleotide polymorphisms (SNPs) has been proposed so that the haplotypes can be used as markers in association studies and to efficiently describe human genetic variation. The International Haplotype Map (HapMap) project to construct a comprehensive catalog of haplotypic variation in humans is underway. However, a number of factors have already been ...
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The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of these estimates, and show that pooling DNA samples is efficient in estimating haplotype frequenc...
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With the consensus human genome sequenced and many other sequencing projects at varying stages of completion, greater attention is being paid to the genetic differences among individuals and the abilities of those differences to predict phenotypes. A significant obstacle to such work is the difficulty and expense of determining haplotypes--sets of variants genetically linked because of their pr...
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Genetic diversity is one of the important and essential characteristics of any population for its survival. The study of genetic variation in different populations of aquatic organisms is of particular importance in order to protect, stabilize and manage their stocks. Based on studies conducted in recent years, molecular markers have proven that they can be used as indicators of the genetic div...
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ژورنال
عنوان ژورنال: Genomics & Informatics
سال: 2016
ISSN: 2234-0742
DOI: 10.5808/gi.2016.14.4.196